An oral antibiotic pill used to deal with frequent eye infections could show an efficient medication for a sexually transmitted bug that has develop into immune to traditional advisable remedy, recommend docs within the journal Sexually Transmitted Infections.
They efficiently handled a younger man with Mycoplasma genitalium (non-gonococcal) urethritis with chloramphenicol.
Information from the UK Well being Safety Company recommend rising antimicrobial resistance to first and second selection medication used to deal with this an infection, whereas there’s at present no sturdy proof for third selection choices, say the authors.
They describe a case of a younger man with recurrent non-gonococcal urethritis signs, a standard sexually transmitted an infection attributable to Mycoplasma genitalium that has develop into more and more tough to deal with with at present advisable antibiotics.
The younger man initially turned up on the clinic with 2-day outdated signs, a fortnight after having unprotected intercourse with an off-the-cuff companion.
He was initially handled with every week’s course of doxycycline, pending take a look at outcomes to determine the precise bacterial reason behind his an infection.
The outcomes confirmed that he was contaminated with M genitalium and he was then prescribed one other antibiotic, azithromycin. As soon as the lab evaluation revealed that it was a remedy resistant pressure, he was then given a 3rd antibiotic, moxifloxacin.
However 5 days after finishing all of the programs of antibiotics, he nonetheless had signs. After contemplating different choices, which had been dismissed resulting from value, availability, or licensing points, the authors determined to strive chloramphenicol: 1g pill taken 4 occasions a day for 14 days.
Their choice was prompted by take a look at tube proof displaying that chloramphenicol stopped M genitalium in its tracks and the prepared availability of the drug.
After 14 days of remedy, the younger man’s signs had cleared up and lab assessments confirmed that he now not had urethritis.
This is only one case, and the findings ought to be taken in that context. However level out the authors: “When contemplating what to decide on after first- and second-line remedy failure, there’s a lack of novel brokers available within the UK, and a paucity of knowledge to underpin suggestions.”
Chloramphenicol is usually properly tolerated, with the intense unwanted effects uncommon (1 in 30,000), they spotlight. And within the absence of viable efficient options, it deserves additional investigation, they recommend.
“Choices for third-line therapies in treatment-resistant M genitalium are urgently required. Chloramphenicol could have an utility on this situation, and ought to be thought of as a potential drug for investigation,” they conclude.
Supply:
Journal reference:
Goodfellow, J.J., et al. (2023) Novel use of oral chloramphenicol for remedy resistant Mycoplasma genitalium. Sexually Transmitted Infections. doi.org/10.1136/sextrans-2022-055621.
